3 edition of Uric Acid As A Factor In The Causation Of Disease V2 found in the catalog.
July 25, 2007
by Kessinger Publishing, LLC
Written in English
|The Physical Object|
|Number of Pages||506|
High uric acid levels – known as hyperuricemia – increase the risk of gout, kidney disease, and early death. Uric acid is the product of the breakdown of purines. - a chronic disorder of uric acid metabolism that manifests as an acute, episodic form of arthritis Causes: overproduction of or decreased excretion of uric acid - form an inherited disorder of purine metabolism or kidney disease - leads to high levels or uric acid in the blood and formation of .
Abstract. Uric acid, the final product of purine catabolism, tends to accumulate in humans due to the lack of the enzyme uricase. Serum uric acid (SUA) higher than 7 mg/dL is defined as hyperuricemia, the main established risk factor for the development of by: 2. Uric acid is a molecule (a byproduct of purine metabolism) that, in excessive levels, can contribute to gout and kidney stones. Despite this, uric acid is a potent antioxidant compound. Learn how to stay healthy during COVID with our free guide — Coronavirus: A guide to staying healthy (and sane) while stuck indoors.
Objective High serum uric acid (UA) levels are associated with the metabolic syndrome, type 2 diabetes and cardiovascular disease. It is largely unknown whether there are gender-specific differences regarding the association between UA and prediabetic states. We examined the possible association between UA levels and known as well as newly diagnosed diabetes (NDD), isolated impaired fasting Cited by: Hyperuricemia is a modifiable condition that can lead to gout, and may be an independent risk factor for cardiovascular events , hypertension [5,6], diabetes  and renal disease [8,9].Reduction of serum uric acid (SUA) level might therefore be an important factor in the prevention of these conditions, with lifestyle modification preferable to pharmacological intervention.
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Uric acid as a factor in the causation of disease: a contribution to the Item Preview. Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5 H 4 N 4 O forms ions and salts known as urates and acid urates, such as ammonium acid acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine.
High blood concentrations of uric acid can lead to gout and are associated with other Beilstein Reference: Pris: kr. Inbunden, Skickas inom vardagar. Köp Uric Acid as a Factor in the Causation of Disease av Alexander Haig på Background Despite abundant epidemiologic evidence, the role of elevated serum uric acid level as a cardiovascular risk factor is controversial.
We assessed the predictive value of serum uric acid levels for cardiovascular and overall mortality. Methods A population-based prospective cohort study was performed of middle-aged Finnish men initially without cardiovascular disease, cancer, or Cited by: Uric acid precipitation and gout.
Gout is common painful rheumatic disease, resulting from the deposition of monosodium urate monohydrate microcrystals or uric acid in various parts of the body, primarily in joints and surrounding tissues due to overproduction or underexcretion of poorly soluble uric acid which is the end product of endogenous and dietary purine metabolism in humans ().Cited by: Elevated SUA level has been recently recognized as a risk factor for the development of the arterial hypertension, subclinical atherosclerosis, stroke and heart failure.
The role of the uric acid as an independent risk factor for the cardiovascular disease is controversial, since hyperuricemia is associated to other traditional risk by: Uric acid in healing and defense: Physiological functions of uric acid Antioxidant.
Most serum uric acid is freely filtered in kidney glomeruli, and approximately 90% of filtered uric acid is reabsorbed, implying that it has a considerable physiological role.In humans, over half the antioxidant capacity of blood plasma comes from uric acid.Uric acid is a strong reactive oxygen species Cited by: According to previous epidemiological or experimental studies, serum uric acid is correlated with disorders such as obesity , diabetes mellitus , hypertension , cardiovascular disease [6.
Uric acid may play a role in causing metabolic syndrome, a cluster of risk factors that increases the risk of heart disease and type 2 diabetes, a new study indicates. Uric acid is a. Keywords: Serum Uric Acid, Heart Failure, Endothelial Dysfunction, Biomarker Cite this article: Alexander E Berezin.
Uric Acid in Heart Failure: Controversy Factor in The Multiple Pathogenesis of The Disease. Biomed J Sci & Tech Res 1(3) BJSTR. DOI: /BJSTR ISSN: Uric acid (UA) remains a risk factor for the progression of chronic kidney disease (CKD).
Most observational studies showed a slight elevation in the serum UA level and this independently predicts. Furthermore, as compared with women who had a uric acid level Cited by: Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove.
We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is Cited by: Uric acid (UA) is the end product of purine nucleotide metabolism and its primary mode of clearance is by renal excretion.
Modifiable factors such as blood pressure, albuminuria, glycemic control, etc., play an important role in the progression of DN and none of them are : K.N. Shashidhar, U. Munilakshmi, K. Prabhavathi, Madhavi Reddy, V.
Lakshmaiah. Uric acid has antioxidant effects on neurons. Abnormally high levels of uric acid are, however, associated with gout. Previous studies have suggested that high levels of uric acid (and the presence of gout) may exert a protective effect against the risk of developing some neurological diseases.
We aimed to investigate this hypothesis in a large database of hospital admissions in by: Previous studies have demonstrated an association of serum uric acid with kidney disease. However, it is unknown whether this relationship is causal. Mendelian randomization takes advantage of allele randomization at birth to assess causation.
Using this technique Ahola et al. found strong evidence against causation in Finnish Caucasians with type 1 diabetes by: 1. A link between uric acid (UA) levels and cardiovascular diseases has been previously reported. However, its importance as a risk factor is still controversial.
This study sought to determine whether elevated serum uric acid levels are associated with cardiovascular disease (CVD) in middle-aged and elderly Chinese individuals.
We conducted a population-based cross-sectional study in Shanghai Cited by:. Uric acid is naturally produced by the body and may have helped our ancestors retain fat and sodium. But, excess uric acid can boost our risk for gout, high blood pressure, stroke, heart disease, and diabetes.
Uric Acid and Disease. Consumption of dairy products is associated with increased risk for Parkinson’s disease. Milk lowers uric acid.
Hyperuricemia is a prevalent finding in patients presenting metabolic syndrome, although its clinical meaning is still controversial and often underestimated.
Men and women have different serum urate levels at all ages, and the impact of hyperuricemia in cardiovascular and renal outcomes is generally associated with a worse prognosis in women.
Recent studies also have called attention to Cited by: The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population.
Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional Cited by: